Unfortunately, Titan Corporation is not without its enemies - rival corporations seeking to undermine its operations, raiders and bandits seeking to steal its resources, military operations seeking to claim an outpost for their own use, bizarre space entities that may dislike the ROME's intrusion on their territory…

As a rule, most rounds have at least one player (and often several) taking on the role of the round's adversary, responsible for wreaking havoc on the station. Some rounds have NPC adversaries as well, either as a primary focus or as subsidiary troublemakers.